Journal article
Translating the biology of β common receptor-engaging cytokines into clinical medicine
H Pant, TR Hercus, DJ Tumes, KH Yip, MW Parker, CM Owczarek, AF Lopez, DP Huston
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2023
Abstract
The family of cytokines that comprises IL-3, IL-5, and GM-CSF was discovered over 30 years ago, and their biological activities and resulting impact in clinical medicine has continued to expand ever since. Originally identified as bone marrow growth factors capable of acting on hemopoietic progenitor cells to induce their proliferation and differentiation into mature blood cells, these cytokines are also recognized as key mediators of inflammation and the pathobiology of diverse immunologic diseases. This increased understanding of the functional repertoire of IL-3, IL-5, and GM-CSF has led to an explosion of interest in modulating their functions for clinical management. Key to the successf..
View full abstractGrants
Awarded by CSL Behring
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) to H.P., D.J.T., and A.F.L. (APP2004288) and to A.F.L. and M.W.P. (APP1071897) ; from the Cancer Council Victoria to M.W.P. (APP1123401) ; from the Australian Research Council to M.W.P. (DP220101788) ; from the Australian Cancer Research Foundation to M.W.P.; from the National Institutes of Health National Institute of Allergy and Infectious Diseases (RO1 AI097372) to D.P.H.; and the W. Bryan Trammell Jr. Family Endowment to D.P.H. Funding from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute is acknowledged. M.W.P. is an NHMRC Research Fellow (APP1117183) and an NHMRC Leadership Fellow (APP1194263) .